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5 Things to Know When Starting a GLP-1 RA Therapy: GLP-1 RA medications are meant to be taken long-term as chronic treatments

However, large visceral deposits in obese women have been linked to suppression of the antilipolytic effect of insulin, and increased levels of free fatty acids have been found in the hepatic portal in individuals with upper body obesity 75,76

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The LEADER trial demonstrated cardiovascular benefits with liraglutide while other large outcome studies show GLP 1 medications improve endothelial function, reduce blood pressure modestly and favorably modify inflammatory and lipid markers