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Olfactory bulb Up to 20% of adults with COVID-19 infected individuals exhibit anosmia/hyposmia and ageusia, which is a neurological symptom, at an early stage of the viral illness [21]

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In addition, in response to a single bout of resistance exercise, plasma NO metabolites, nitrate and nitrite, and cyclic guanosine monophosphate (cGMP) were elevated 30 min following exercise [7]

Furthermore, decreased NAD+ levels, potentially a consequence of reduced kynurenine, may contribute to fatigue by impairing energy production, and disrupting the coordination of circadian rhythms necessary for effective sleep (reviewed in Dehhaghi et al., 2022)

Cytokines mediated inflammation and decreased neurogenesis in animal models of depression