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Meanwhile, glutamate antagonists (e.g., NMDA receptor inhibitors) are being investigated for diseases where glutamate toxicity is a contributing factor, such as stroke and Alzheimer's disease

Two groups have shown that treatment of rats with a NOS inhibitor induced mesenteric perivascular mast cell degranulation, and this was associated with enhanced mast cell-dependent leucocyte adhesion to the vascular endothelium and increased gut epithelial permeability [61,62]