The presence of GLP-1 receptors in the central nervous system, particularly in the ventral tegmental area (VTA) and nucleus accumbens (NAc), suggests their involvement in reward processing and motivation
While gallstone risk cannot be entirely eliminated, strategies that may help include following the prescribed gradual dose titration schedule, maintaining adequate dietary fat intake with meals, aiming for gradual rather than rapid weight loss, and attending regular follow-up appointments for symptom monitoring
The pharmacokinetics of GLP-1 receptor agonists create windows of peak activity, troughs of reduced effect, and transition periods where side effects hit hardest
N Engl J Med (2021) 385:50315
Do not use sterile water, saline, or tap water