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At the highest dose tested, participants in the retatrutide group achieved mean body weight reductions of approximately 24% a figure that exceeded results previously reported for single-agonist (semaglutide) and dual-agonist (tirzepatide) compounds at comparable trial stages

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N., Lopez-Tello, J

GLP-1 medications carry a boxed warning for thyroid C-cell tumors (medullary thyroid carcinoma) based on rodent studies, though no conclusive increase in human cases has been established