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It may be important to point out that despite being associated to many human diseases, and with human studies/clinical trials showing low to moderate efficiency in few cases (detailed subsequently for T2D and neuroprotective effects), effective translation of the modulators of ROS into the clinics is yet highly awaited [24]

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The Effect of PDRN, an Adenosine Receptor A2A Agonist, on the Healing of Chronic Diabetic Foot Ulcers: Results of a Clinical Trial