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Importantly, Akt/PKB also phosphorylates forkhead transcription factors of the FOXO subfamily, and this leads to their inactivation and retention in cytoplasm[254, 255] resulting in a reduced transcriptional activity[256]

After about four weeks, the dose can be increased to 0.5 mg or more if needed

Kung YA, Chiang HJ, Li ML, Gong YN, Chiu HP, Hung CT, et al

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