Cardiovascular effects beyond cardiac hypertrophy are poorly characterized for IGF-1 DES specifically, though IGF-1 influences cardiovascular physiology through effects on vascular smooth muscle, endothelial function, blood pressure regulation, and cardiac contractility - chronic perturbation of these processes carries unknown risks
Better Absorption for Some Individuals: People with certain medical conditions, such as pernicious anemia or gastrointestinal disorders like Crohns disease, might not absorb enough vitamin B12 from food
Others only notice symptoms at higher doses such as 1.0 mg or 1.7 mg
Furthermore, it has been shown to exert anti-inflammatory effects (9), improve skin injuries as well as showing benefits in improving normal skin and hair by compensating for age-related damage (10)
When research on a particular compound comes almost exclusively from one geographic region and institutional network, there is inherent risk of confirmation bias, methodological preferences that favor positive findings, and results that may not generalize to other populations or research contexts
