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California E-Cig Regulations One of the major contributing factors to the uncertainty surrounding the safety of e-cigarettes is the lack of official legislation and regulation, but some states have enacted their own regulations and laws for e-cigarette sale and use

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However, the incidence of lung adenocarcinomas did not similarly decrease for men and women, exceeding squamous cell cancers in about 1990 and currently comprising about 60% of nonsmall cell lung cancers (Figure 1A)

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