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You may need a dose adjustment rather than a timing change

EEM has received speakers honoraria from Merck Canada, and the University of Ottawa Heart Institute receives funding from Merck for preclinical studies in EEMs laboratory

However, the interesting part of this study mentioned how as the animals aged there was no clear reduction in longevity despite the obesity that developed, but when these animals were placed on a low-fat diet, lifespan increased by 30%

Side effects were manageable, and researchers concluded that this higher starting dose was safe