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Significant caloric deficits, particularly when rapid or severe, can temporarily affect cognitive function

Their high efficacy and low off-target toxicity continue to transform oncology, immunology, metabolic disease, and vaccinology [1, 6,7,8,9,10,11]

There are also other practical reasons to prescribe these drugs in people with type 2 diabetes, because all three classes are associated with relatively low risk of hypoglycemic events, while patients treated with GLP-1RA and SGLT-2 inhibitors may also benefit from weight loss [11]

If long-term therapy is shown to be necessary to maintain health benefits, it may strengthen the case for broader insurance coverage and more consistent access to these medications. Overall, these studies reinforce the growing recognition of obesity as a long-term medical condition