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The importance of oxidative stress in schizophrenia has been proposed already in the middle of the twentieth century (Hoffer et al

Meanwhile, obesity or overweight, worse renal function, unfavorable lipid profile (such as higher low-density lipoprotein cholesterol and lower high-density lipoprotein cholesterol), hypertension, and smoking are also associated with a higher risk of DPN ( 2.3 Pharmacological treatments for DPN According to the relevant guidelines in China released in 2021 ( 3 Preclinical evidence of neuroprotective effects of GLP-1R agonists in DPN In patients with DM, the metabolism of glucose, lipids, proteins, and nuclear acids is largely dysregulated