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Overall, 154 subjects completed the trial and two subjects were prematurely withdrawn before trial completion: one subject was withdrawn from reference arm night30 min by the investigator due to an adverse event suggestive of COVID-19 infection and one subject withdrew themself from treatment arm 2 hnight

The effects are not permanent, and maintenance doses are needed to sustain skin brightness and health benefits

The relationship between body weight and optimal dosing has not been established through controlled trials

The supernatant was removed and the total protein concentration was measured by Bradford assay