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The accumulation of gut microbiome-derived indoxyl sulfate and P-cresyl sulfate in patients with end-stage renal disease

Most peptides require specialized transport mechanisms or fail to cross the BBB entirely when administered peripherally, but Dihexa achieves therapeutic CNS concentrations through standard subcutaneous or oral routes

Regulatory acceptance varies by region, with formal approval in certain therapeutic settings and off-label use prevalent in others under clinical supervision

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