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The effort involved limits practical application for most users

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In RA patients, HK2 is highly expressed in the synovium, and it inhibits apoptosis and promotes FLS proliferation by acting on mitochondrial channel VDAC ( HK2 gene silencing reduced FLS migration and invasiveness by 62% and 78%, respectively, while its overexpression significantly enhanced lactic acid production and synovial hyperplasia ( Significant progress has been made in targeted intervention strategies against HK2

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Step 4 Ongoing Monitoring: Labs at 68 weeks and quarterly thereafter