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When the body tries to perform necessary chemical processes with missing or altered components, it can cause problems

Notably, a chronic high-fat diet positively regulates ZDHHC3 expression, exacerbating hepatic lipid deposition, a process that in turn further promotes ZDHHC3 expression, creating a self-reinforcing vicious cycle

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Hanson, L

10.1186/s13024-020-00363-x Mol