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T cells accumulate in the intestine before arthritis onset To investigate cellular intestinal alterations that precede the onset of arthritis in more detail, we analyzed T-cell subsets in the intestine at different time points during the CIA time course

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The evidence and the missing genetic layer The compound class carries a deep trial record: STEP for semaglutide in weight management (NEJM 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM 2024)

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Mientras que la metformina ha sido durante dcadas el tratamiento de primera lnea para la diabetes, la tirzepatida es un agonista dual de receptores GIP/GLP-1 aprobado tanto para diabetes (Mounjaro) como para control crnico del peso (Zepbound)