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A 2026 UK review of the standardised EGb 761 extract, the decisive Laws 2012 meta-analysis showing no effect in healthy adults, the null GEM and GuidAge prevention trials, the modest 240 mg benefit in mild dementia, dosing and the bleeding risk versus Dihexas unproven HGF/c-Met synaptogenesis and the c-Met concern

Since its identification, over 28,000 research papers have described its relevance to several inborn errors of metabolism, B vitamin status, and diseases as diverse as cardio- and cerebrovascular disease, dementia, renal disease, thyroid disease, and pregnancy complications, to name but a few

The extra time at each step does not reduce the eventual effectiveness of higher doses

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