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Large clinical trials of GLP1 medicines, such as Ozempic and Wegovy, have shown benefits on heart health beyond weight loss

A meta-analysis of 5 trials (n=20,387) estimated that SGLT2i use in people with advanced diabetic kidney disease reduced the risk of kidney failure by 31% (HR 0.69, 95% CI 0.57 to 0.83) [58] Note that this is over and above the effect of both BP control and use of RAASis

No consistent trends in HRs were seen with cumulative duration of GLP-1RA use (ESM Table 4)

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Their main actions include: Slowing gastric emptying This means food leaves the stomach more slowly, promoting a longer feeling of fullness after meals and reducing the post-meal rise in blood glucose