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To view a copy of this license, visit About this article Cite this article Alkilany, A.M., Alsotari, S., Alkawareek, M.Y

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Ca 2+ is a master regulator of eryptosis, mediating the Gardos effect-associated RBC dehydration and reduction of cell volume (cell shrinkage), calpain activation-mediated cytoskeleton remodeling (membrane blebbing), and PS externalization, which are major hallmarks of eryptosis