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These medications are supported by extensive randomized controlled trial data and are recommended by the American Diabetes Association (ADA) as preferred agents for many patients with type 2 diabetes, particularly those with established cardiovascular disease or chronic kidney disease

Hunger JM, Major B, Blodorn A, Miller CT

Further, in fructose HFD-induced models, ovariectomy has been shown to reverse the reduced susceptibility of female mice to liver damage 92

For instance, NSAIDs used by RA patients to inhibit prostaglandin physiological functions can elicit gastrointestinal reactions like gastric and duodenal ulcers, bleeding, and cardiovascular and hematological disturbances stemming from coagulation disturbances

It was observed to have a multifunctional role