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Tangs team had shown in a February 2018 PNAS article that e-cigarette smoke induces DNA damage in the mouse lung and bladder, and that nitrosation in cultured human lung and bladder cells converts nicotine into derivatives that increase DNA code changes, or mutations, with the potential to transform normal cells into cancer cells

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Considering these limitations, future studies that include different platforms, broader inclusion criteria, and larger sample sizes could offer more comprehensive insights

Gradual Reduction Strategy A successful nicotine replacement therapy plan is to gradually reduce your nicotine intake, typically by following a 12-week tapering plan for nicotine gum, where you gradually reduce the number of pieces used each day

It was surprisingly flexible once it started opening up