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The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52
Moreover, the suppression of fat intake from systemic OEA is prevented when a mixed dopamine 1 receptor (D1R) and dopamine 2 receptor (D2R) antagonist is infused into the dorsal striatum [104]
Clinical trials have also reported that onion (quercetin-rich source) intake for 24 weeks reduced cognitive decline, possibly by reducing depressive symptoms and improving emotional state, compared to placebo food group, in Japanese individuals of age-group 6079 years [97]
Ozempic has also demonstrated significant weight loss effects, with patients losing up to 15% of their body weight
*Correspondence: Jos Andrs Yunes, [email protected] Present address: Rafael Renatino Canevarolo, Department of Cancer Physiology, H
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