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42 Interestingly, maxadilan, a peptidic PAC1R agonist, reorganized the ECD orientation and reshaped the ligand-binding pocket conformation, including ECL1 42 (Fig

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Given the extensive and heterogeneous body of literature availablecharacterized by varying levels of evidence qualityreaders are referred to dedicated, topic-specific reviews for more comprehensive insights and detailed analyses [108,109,110]