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Some people with UC may have weight loss or other systemic symptoms (symptoms that affect the entire body)

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Because of the difficulty of identifying specific sinusoidal cell types from H&E-stained sections, definitive diagnosis of endothelial cell hypertrophy/karyomegaly requires confirmation using special stains

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Chitnis MM, Yuen JSP, Protheroe AS, Pollak M, Macaulay VM