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While manufactured seals are factory tested to assure compliance with ISO and/or YBB flip-off force specifications as a matter of quality control, crimped and conditioned vials may need to be demonstrated to meet certain minimum flip-off force specifications to ensure that seal caps do not disengage during transportation and storage

Pharmacists should inform patients about the potential for altered skin sensation, including sensitivity, pain, or burning

Its now also available as a daily pill and as a higher-dose injectable version, Wegovy HD 7.2 mg, all made by the company Novo Nordisk

Quick answer In the REDEFINE trials CagriSema is given once weekly by subcutaneous injection, with both components titrated in parallel from 0.25 mg + 0.25 mg up to a 2.4 mg + 2.4 mg weekly target