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The strongest association signals for baseline GR/HGA were within a locus on chromosome 7 containing two central genes: TAC1 (protachykinin-1) that has been linked to depression and anxiety 85 and ASNS (asparagine synthetase [glutamine-hydrolyzing]) that is an important enzyme, the deficiency of which leads to substantial neurodevelopmental deficits 86

Some IgG subtypes form immune complexes with oxLDL that stimulate an inflammatory macrophage response and thereby worsen plaque development, while others may be atheroprotective 3,126,133 (Fig

Cystic fibrosis sputum rheology correlates with both acute and longitudinal changes in lung function