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Switching between GLP-1 agonists is sometimes the answer when one medication causes intolerable GI effects but the therapeutic benefits are too significant to abandon entirely
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There are also some serious side effects such as thyroid tumours, kidney problems, and many more
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Some variants are assigned as P/LP based on classification as high prediction of loss-of-function based on protein effects (e.g., nonsense, frameshift, large deletions, etc.)
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