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This is particularly important because SGLT2 inhibitors and GLP-1 RAs are associated with lower risk of hypoglycemia and individuals with ASCVD, HF, and CKD have higher hypoglycemia risk than individuals without these conditions (136)

That is a paradigm shift for a condition that cardiologists have struggled to treat for decades

For example, SLN-loaded HSP reduced oxidative stress and restored antioxidant enzyme levels in a doxorubicin-induced cardiotoxicity model [83], while optimized SLN-HSP formulations showed improved anti-inflammatory activity in vivo [84]

We also know very little about what happens to binge eating symptoms after treatment is discontinued, making this another key priority for future research

10.1186/s13024-025-00857-6 476 WeisS.SchwiertzA.UngerM