Cagrilintide and retatrutide are two investigational peptide-based medicines currently being studied for the treatment of obesity and related metabolic conditions
Inhibitors like FK866 and CHS828, which are based on heterocyclic structures and act by binding to the active site of NAMPT 215,216 , are being investigated for their potential to selectively target cancer cells by exploiting their high NAD + turnover 214
Results vary by goal and individual response
BPC-157 shows stronger preclinical evidence for tendon and ligament healing, thanks to its effects on angiogenesis, fibroblast activity, and collagen remodeling
J Physiol Paris 95:295301 Prkacin I, Separovic J, Aralica G et al (2001b) Portal hypertension and liver lesions in chronically alcohol drinking rats prevented and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine