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Stem Cells Transl Med

For example, Bifidobacterium bifidum [138], with its hypoxia tropism, has been used to covalently modify calcium phosphate/silica nanoparticles loaded with doxorubicin, constructing the DNPs@Bi system that can actively target chemotherapy drugs to the hypoxic core of tumors, achieving effective killing of solid tumors through the combination of chemotherapy and immunogenic cell death effects

PMCID: PMC3155927

Symptoms such as nausea, dizziness, or severe fatigue should be reported to a healthcare professional immediately

This is the foundation phase not a side effect, but the intended starting signal