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The parent protein was first isolated in the 1990s by a Croatian research group led by Dionis Sikiric, who would go on to publish the majority of foundational BPC-157 studies

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In hepatocellular carcinoma, hypoxia upregulates SLC7A11 by inhibiting the expression of methyltransferase 14 (METTL14), further suppressing ferroptosis (211)

However, spacing coffee and supplements apart can help avoid competition during digestion and absorption