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This led the FDA to place a lifetime ban in 1985 on men who have sex with men from donating blood, though 20 years later it loosened guidelines to include gay and bisexual men who abstained from sex with men for at least a year

However, higher doses may carry the risk of other adverse effects, including agitation and activation

Last but not least, by reducing the dose and avoiding systemic distribution, nasal delivery of GLP-1 drugs should alleviate gastrointestinal and other adverse events, offering a promising approach for maximizing the therapeutic effects GLP-1 drugs with potentially increased compliance and safety

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The anecdotes are compelling