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Although challenges such as limited bioavailability and safety concerns continue to impede clinical translation, these limitations may be addressed through the optimization of delivery strategies, rigorous pharmacokinetic and toxicological assessments, mechanism-driven in vitro , in vivo , ex vivo studies, and well-designed clinical trials

These side effects typically occur at the start of treatment and when switching to a higher dosage but tend to improve with time

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However, GLP-1 is only able to create these effects for a short time-span due to the fact that it disappears over time

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