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What This Means for Experimental Design IGFBP Interactions: Degree of Reduction Differs Both analogs reduce IGFBP binding, but not equally: IGF-1 LR3 achieves approximately 1,000-fold reduction in affinity for all major IGFBPs

Human cells are not the same as a human trial Studied in human cells means the cells originated from human tissue

FASEB J 15:11811186 Morgan MT, Nakanishi Y, Kroll DJ, Griset AP, Carnahan MA, Wathier M, Oberlies NH, Manikumar G, Wani MC, Grinstaff MW (2006) Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro

4 , e673e673 (2013)

The first study lasted 60 days and both groups followed a low-calorie diet