Linus Pauling Institute Oregon State University Updated in January 2014 by: Barbara Delage, Ph.D

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The study was small and had no comparison group, but the fact that relief lasted many months is noteworthy
However, if your body has trouble absorbing nutrients (which is common after certain GI conditions or surgeries), your provider may recommend B12 injections
Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials