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Importantly, estrogens and their metabolites can cause cholestasis in pregnant women and premenopausal women who receive oral contraceptive or use hormone replacement therapy, especially in susceptible people (Schreiber and Simon, 1983

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Possibly adding a new entrant to the highly competitive diabetes/weight loss market, Roche has announced positive interim results from an ongoing Phase I trial for its oral small molecule GLP-1 receptor agonist, CT996