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That framing, while common, is imprecise enough to be dangerous for anyone making strategic decisions based on it

Figure 1 from Colhoun , et al, Nat Med 2024 Even if semaglutide saves lives, hearts, and kidneys, and FLOW is a global trial, implementation of the so-called fourth pillar remains a local challenge

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Notably, in January 2025, the FDA granted accelerated approval for sotorasib in combination with immunotherapy for adults with KRAS G12C-mutated colorectal cancer, further reinforcing its potential across multiple tumour types