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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)
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Bs MntR forms noncognate metal complexes with Fe II , Zn II and Co II , that are mononuclear, rather than binuclear Mn II complex, and do not allosterically activate DNA operator binding (Figure 15C)
Adults over 50 Intrinsic factor production declines with age
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