A : Most users notice progress within the first few weeks
GLP-1RAs and SGLT2 inhibitors also have pleiotropic effects, including blood glucose-dependent and -independent mechanisms, effects on the reninangiotensinaldosterone system and favourable effects on left ventricular and renal functions [35, 36]
It plays a vital role in stimulating insulin secretion, slowing gastric emptying, and reducing appetite, thus helping maintain balanced blood sugar levels and supporting weight management
Second, improvements in IR and glycaemic indices are most apparent in higher-burden phenotypes, particularly in women with impaired glucose tolerance/prediabetes or related metabolic comorbidities, where changes in HOMA-IR, fasting glucose and OGTT profiles are more pronounced and may plausibly reduce periconception metabolic risk
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