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In most instances, they are removed for esthetic concerns

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Leone A., Diorio G., Sexton W., Schell M., Alexandrow M., Fahey J.W., Kumar N.B

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49 , who reported that conversion of the N-terminal histidine (His) of Ex-4 to phenylalanine (Phe) resulted in reduced GLP-1R-mediated internalization and prolonged signal response