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Building on these reference trials, we specified two protocols that expanded eligibility to assess the effectiveness of semaglutide versus sitagliptin and tirzepatide versus dulaglutide in populations reflective of patients routinely seen in clinical practice, spanning low, moderate or high cardiovascular risk (Supplementary Table 26)

Treatment typically begins with a low starting dose , which is gradually increased every 14 weeks (depending on the agent) until the target maintenance dose is reached or the maximum tolerated dose is achieved

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It can help protect nerves, improve cardiac output, and reduce inflammation

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