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PMID 25596811
First Principle: Proportionality A defining feature of chronic energy flux constriction is that gradual shifts in substrate availability may reduce ATP/NADH generation efficiency and redox buffering reserve without exceeding conventional diagnostic thresholds
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Hyperlipidemia is common in patients with type 2 diabetes, the condition may induce increased production of lipid peroxides which is an indication of a decline in the cellular antioxidant defense mechanism
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