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Nicotine causes thickening of the blood vessels, which hampers the blood flow and also causes high blood pressure or hypertension, Mukesh Goel, Senior Consultant, Cardio Thoracic & Vascular Surgery at Indraprastha Apollo Hospitals, told IANS

doi: 10.1007/978-1-60327-492-0_5

With respect to safety, NPs were generally very well tolerated with no serious AEs noted after administration, while six participants reported minor AEs (dizziness, headache, hot flush, hyperhidrosis and back pain) that resolved quickly