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Circulating endogenous GLP-1 has a half-life of 1-2 minutes, being rapidly inactivated by dipeptidyl-peptidase IV

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Alcohol consumption : As a practical consideration only, some clinicians suggest avoiding injection on evenings when significant alcohol consumption is anticipated, to avoid compounding nausea though this is not established in UK product information

As GLP-1 receptor agonists such as semaglutide become more widely used in the management of both diabetes and obesity, physicians may encounter situations where these medications appear to intensify previously silent gastrointestinal conditions