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Aquilano K, Baldelli S, Ciriolo MR

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Pairing these with GLP-1 supplements can enhance results

In vivo and in vitro experiments clarify the hierarchical regulatory mechanisms: Butyrate directly regulates Th17/Treg homeostasis, promotes Treg differentiation through the HDAC1/FoxP3 pathway, and simultaneously inhibits Th17 activation and the expression of IL-17, IL-23, and RORt (89, 90)