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D.ChatterjeeS.ChangD.MironchikY.et al (2019)

Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means

Usually after a trip to the vet, shed pass out asleep, but she was playing like a little kitten. Nix credits the shot, not the enema

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