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Because of its principal renal excretion and clearance, dose modification is needed in patients with moderate-to-severe renal impairment to avoid drug accumulation and, likely, toxicity
There are several UCP family members in humans and several of the encoding genes are induced under high-fat diet conditions
Food noise is the kind of mental preoccupation that disrupts focus, drives impulsive eating decisions, and makes it nearly impossible to stick to a plan even when your intentions are solid
Figure 1 4.1.1 Cardiovascular outcomes in SGLT2 inhibitors: safety studies The EMPA-REG OUTCOME trial, which included 7020 patients with T2DM, was the first to demonstrate the cardiovascular protective effects of empagliflozin ( Subsequent trials, such as CANVAS and DECLARE-TIMI 58, have further confirmed the cardiovascular benefits of SGLT-2 inhibitors
Gastrointestinal (GI) Nausea (most common, especially during the first few weeks)
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