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There has been a notable increase in the number of patients with T2DM due to the global rise in obesity, driven by sedentary lifestyles and regular consumption of energy-dense diets ( Glucagon-like Peptide-1 (GLP-1, 3031 aa) is a natural gastrointestinal incretin hormone of the glucagon peptide family, secreted from the enteroendocrine L-cells in the distal gut to stimulate insulin secretion in response to postprandial hyperglycemia (Figure 1)

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