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"As we embrace their promise, we must also confront one of the greatest healthcare conundrums of our time: how to ensure these treatments remain accessible to those who need them most while preventing financial strain on healthcare systems, employers and individuals," Evernorth analysts wrote

These patients exhibit elevated levels of fumarate and develop hereditary leiomyomatosis and renal cell cancer (HLRCC), a syndrome characterized by smooth muscle tumors and papillary renal cell carcinoma type 2 (pRCC-2

Lower doses are often sufficient for the final stretch and for maintenance

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